Electrochemistry is a well-studied method for the mimicry of drug metabolism that is complementary to other in vitro techniques like liver microsomal incubations. Additionally, exciting developments have been reported in recent years with respect to protein analysis comprising the electrochemical reduction of disulfide bonds, important for biopharmaceutical protein analysis, and the specific cleavage of peptide bonds, relevant for proteomics.
In this project, the aim is to develop microfluidic chips for in-situ analysis to gain a better understanding of the reactions occurring at the electrode-solution interface. This microfluidic chip will contain ordered nanofabricated structures for surface enhanced Raman spectroscopy (SERS), or structures for surface enhanced infrared absorption spectroscopy (SEIRAS). SEIRAS and SERS are two complementary methods, since vibrations active in SERS are inactive in SEIRAS and vice versa. Moreover, enhancement of the spectroscopic methods is essential to lower the limit of detection.
This post-doctoral position focusses on using the developed SERS and SEIRAS devices to study relevant reactions in the field of proteomics and drug screening in detail.
For detailed information and to get a better impression of the kind of work in this project, the following papers are recommended:
- Electrochemical protein cleavage in a microreactor: http://eprints.eemcs.utwente.nl/27326/
- Drug screening in a microreactor: http://pubs.rsc.org/-/content/articlehtml/2016/lc/c6lc00708b
- In-situ spectroelectrochemistry: http://eprints.eemcs.utwente.nl/26002/
We are looking for a candidate with a PhD in analytical chemistry. Most importantly that includes experience in electrochemistry. Additionally experience with any of the used analytical methods such as infrared spectroscopy, Raman spectroscopy, or mass spectrometry is greatly appreciated. Moreover, knowledge or experience in operating microfluidic chips is considered as another key advantage. The candidate should be able to work independently, and have excellent theoretical and experimental skills. Fluent command of English is required.
Most importantly, the BIOS Lab-on-a-Chip group in general, and this project in particular are very challenging multidisciplinary environments. It is therefore essential to show willingness to look beyond disciplinary boundaries, to learn new techniques and skills required for this project. This post-doctoral researcher position involves frequent travel between the research groups in Groningen and Enschede. Willingness to conduct such travel is mandatory.
This is a Post-doctoral researcher position for the duration of 3 years. Salary and conditions are in accordance with the Collective Labor Agreement (CAO) of the Dutch Universities. The gross monthly salary starts at € 3255,- (scale 10, level 4) gross per month excluding allowances in accordance with the job profile ‘post-doctoral researcher’, under the University System for Job Classification (UJC).
Bedrijfsprofiel Universiteit Twente
The University of Twente. We stand for life sciences and technology. High tech and human touch. Education and research that matter. New technology which leads change, innovation and progress in society. The University of Twente is the only campus university of the Netherlands; divided over five faculties we provide more than fifty educational programmes. We have a strong focus on personal development and talented researchers are given scope for carrying out groundbreaking research.
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